Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents

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Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors.

Retrotransposons have clearly molded the structure of the human genome. The reverse transcriptase coded for by long interspersed nuclear elements (LINEs) accounts for 35% of the human genome, with 8-9 x 10(5) copies of the most common human LINE element, L1Hs. Retrotransposons cycle through an RNA intermediate with transcription as the rate limiting step. Because various retrotransposons have b...

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ژورنال

عنوان ژورنال: Mutagenesis

سال: 2002

ISSN: 1464-3804

DOI: 10.1093/mutage/17.3.193